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Article

Role of Bacterial and Host DNases on Host-Pathogen Interaction during Streptococcus suis Meningitis.

International journal of molecular sciences - 25 Jul 2020

Meurer Marita, Öhlmann Sophie, Bonilla Marta C, Valentin-Weigand Peter, Beineke Andreas, Hennig-Pauka Isabel, Schwerk Christian, Schroten Horst, Baums Christoph G, Köckritz-Blickwede Maren von, de Buhr Nicole

Abstract excerpt

Streptococcus suis is a zoonotic agent causing meningitis in pigs and humans. Neutrophils, as the first line of defense against S. suis infections, release neutrophil extracellular traps (NETs) to entrap pathogens. In this study, we investigated the role of the secreted nuclease A of S. suis (SsnA) as a NET-evasion factor in vivo and in vitro. Piglets were intranasally infected with S. suis strain 10 or an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32722502
DOI: 10.3390/ijms21155289
PMCID: PMC7432635

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