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Article

Erbb4 regulates the oocyte microenvironment during folliculogenesis.

Human molecular genetics - 10 Oct 2020

Veikkolainen Ville, Ali Nsrein, Doroszko Milena, Kiviniemi Antti, Miinalainen Ilkka, Ohlsson Claes, Poutanen Matti, Rahman Nafis, Elenius Klaus, Vainio Seppo J, Naillat Florence

Abstract excerpt

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders leading to infertility in women affecting reproductive, endocrine and metabolic systems. Recent genomewide association studies on PCOS cohorts revealed a single nucleotide polymorphism (SNP) in the ERBB4 receptor tyrosine kinase 4 gene, but its role in ovary development or during folliculogenesis remains poorly understood. Since no...

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PMID: 32716031
DOI: 10.1093/hmg/ddaa161

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