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Inherited mutations in fallopian tube, ovarian and primary peritoneal carcinoma: Changes in diagnoses and mutational frequency over 20 years.

Gynecologic oncology - 1 Oct 2020

Weiss Arielle S, Swisher Elizabeth, Pennington Kathryn P, Radke Marc, Khasnavis Nithisha, Garcia Rochelle L, Kilgore Mark R, Lee Ming K, Norquist Barbara M

Abstract excerpt

OBJECTIVES: Women with fallopian tube carcinoma (FTC) are reported to have a higher frequency of inherited BRCA mutations than those with ovarian carcinoma (OC) or primary peritoneal carcinoma (PPC). We hypothesized that routine serial sectioning of fallopian tubes would increase the proportion of cases designated as FTC and change the frequency of inherited mutations between carcinoma types. METHODS: Eight...

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PMID: 32709535
DOI: 10.1016/j.ygyno.2020.06.509

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