Article
Chronic myeloid neoplasms harboring concomitant mutations in myeloproliferative neoplasm driver genes (JAK2/MPL/CALR) and SF3B1.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2021
Ok Chi Young, Trowell Kevin T, Parker Kyle G, Moser Karen, Weinberg Olga K, Rogers Heesun J, Reichard Kaaren K, George Tracy I, Hsi Eric D, Bueso-Ramos Carlos E, Tam Wayne, Orazi Attilio, Bagg Adam, Arber Daniel A, Hasserjian Robert P, Wang Sa A
Abstract excerpt
JAK2, CALR, and MPL are myeloproliferative neoplasm (MPN)-driver mutations, whereas SF3B1 is strongly associated with ring sideroblasts (RS) in myelodysplastic syndrome (MDS). Concomitant mutations of SF3B1 and MPN-driver mutations out of the context of MDS/MPN with RS and thrombocytosis (MDS/MPN-RS-T) are not well-studied. From the cases (<5% blasts) tested by NGS panels interrogating at least 42 myeloid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.