Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PIK3CA vascular overgrowth syndromes: an update.

Current opinion in pediatrics - 1 Aug 2020

Hughes Meagan, Hao Michelle, Luu Minnelly

Abstract excerpt

PURPOSE OF REVIEW: Over the past decade many previously poorly understood vascular malformation disorders have been linked to somatic activating mutations in PIK3CA, which regulates cell survival and growth via activation of the mTOR1-AKT pathway. The goal of this article is to describe and provide an update on the clinical features, complications, and management strategies for the PIK3CA-related overgrowth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Growth Disorders
Share to Mosaicism
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Abnormalities, Multiple

Share to Biomarkers

Share to Musculoskeletal Abnormalities

Share to Syndrome

Share to Vascular Malformations

Source

Identifiers

PMID: 32692051
DOI: 10.1097/MOP.0000000000000923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIK3CA vascular overgrowth syndromes: an update.PMID 32692051Read ↗

Vascular malformations syndromes: an update.Semantic proximity Read ↗

Capillary Venous Malformation With Undergrowth and Activating PIK3CA Variant: An Underrecognized Phenotype.Semantic proximity Read ↗

A review of mechanisms of disease across PIK3CA-related disorders with vascular manifestations.Semantic proximity Read ↗

PIK3CA-related overgrowth spectrum (PROS): diagnostic and testing eligibility criteria, differential diagnosis, and evaluation.Semantic proximity Read ↗

CLOVES syndrome: review of a PIK3CA-related overgrowth spectrum (PROS).Semantic proximity Read ↗

Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum.Semantic proximity Read ↗

Updates on Diagnosis and Treatment of PIK3CA-Related Overgrowth Spectrum.Semantic proximity Read ↗

Somatic PIK3R1 variation as a cause of vascular malformations and overgrowth.Semantic proximity Read ↗

Work-Up and Treatment Strategies for Individuals with PIK3CA-Related Disorders: A Consensus of Experts from the Scientific Committee of the Italian Macrodactyly and PROS Association.Semantic proximity Read ↗

Clinical phenotype of the PIK3R1-related vascular overgrowth syndrome.Semantic proximity Read ↗

[PIK3CA-related overgrowth syndrome (PROS)].Semantic proximity Read ↗

Klippel-Trenaunay Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.