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Article

Nighttime Blood Pressure Interacts with APOE Genotype to Increase the Risk of Incident Dementia of the Alzheimer's Type in Hispanics.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Melgarejo Jesus D, Aguirre-Acevedo Daniel C, Gaona Ciro, Chavez Carlos A, Calmón Gustavo E, Silva Eglé R, de Erausquin Gabriel A, Gil Mario, Mena Luis J, Terwilliger Joseph D, Arboleda Humberto, Scarmeas Nikolaos, Lee Joseph H, Maestre Gladys E

Abstract excerpt

BACKGROUND: Dementia of the Alzheimer's type (DAT) impacts Hispanics disproportionately, with almost a twofold elevated risk of developing DAT, as well as earlier onset of the disease, than in non-Hispanic Whites. However, the role of main risk factors for DAT, such as APOE-ɛ4 and blood pressure (BP) levels, remains uncertain among Hispanics. OBJECTIVE: To investigate the association of APOE-ɛ4 and BP levels,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32675415
DOI: 10.3233/JAD-200430
PMCID: PMC7577347

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