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ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer

15 Jul 2020

Abstract excerpt

BACKGROUND: Small cell lung cancer (SCLC) is a more aggressive subtype of lung cancer that often results in rapid tumor growth, early metastasis, and acquired therapeutic resistance. Consequently, such phenotypical characteristics of SCLC set limitations on viable procedural options, making it difficult to develop both screenings and effective treatments. In this study, we examine a novel mechanistic insight in...

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PMID: 32669118
DOI: 10.1186/s13073-020-00760-3

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