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Article

Unravelling the biology of SCLC: implications for therapy.

Nature reviews. Clinical oncology - 1 Sept 2017

Sabari Joshua K, Lok Benjamin H, Laird James H, Poirier John T, Rudin Charles M

Abstract excerpt

Small-cell lung cancer (SCLC) is an aggressive malignancy associated with a poor prognosis. First-line treatment has remained unchanged for decades, and a paucity of effective treatment options exists for recurrent disease. Nonetheless, advances in our understanding of SCLC biology have led to the development of novel experimental therapies. Poly [ADP-ribose] polymerase (PARP) inhibitors have shown promise in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28534531
DOI: 10.1038/nrclinonc.2017.71
PMCID: PMC5843484

Genes

DLL3
ASCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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