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Article

Degradation of nuclear and mitochondrial DNA after γ-irradiation and its effect on forensic genotyping.

Forensic science, medicine, and pathology - 1 Sept 2020

Goodwin Corey, Wotherspoon Andrew, Gahan Michelle E, McNevin Dennis

Abstract excerpt

Forensic genotyping can be impeded by γ-irradiation of biological evidence in the event of radiological crime; that is, criminal activity involving radioactive material. Oxidative effects within the mitochondria of living cells elicits greater damage to mitochondrial DNA (mtDNA) than nuclear DNA (nuDNA) at low doses. This study presents a novel approach for the assessment of nuDNA versus mtDNA damage from a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32656643
DOI: 10.1007/s12024-020-00251-2

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