Article
lncRNA HOTAIR overexpression induced downregulation of c-Met signaling promotes hybrid epithelial/mesenchymal phenotype in hepatocellular carcinoma cells.
Cell communication and signaling : CCS - 11 Jul 2020
Topel Hande, Bagirsakci Ezgi, Comez Dehan, Bagci Gulsun, Cakan-Akdogan Gulcin, Atabey Nese
Abstract excerpt
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are both reversible processes, and regulation of phenotypical transition is very important for progression of several cancers including hepatocellular carcinoma (HCC). Recently, it is defined that cancer cells can attain a hybrid epithelial/mesenchymal (hybrid E/M) phenotype. Cells with hybrid E/M phenotype...
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