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Article

GEF-H1 over-expression in hepatocellular carcinoma promotes cell motility via activation of RhoA signalling.

The Journal of pathology - 1 Dec 2012

Cheng Ibis K C, Tsang Bruce C K, Lai Keng Po, Ching Arthur K K, Chan Anthony W H, To Ka-Fai, Lai Paul B S, Wong Nathalie

Abstract excerpt

The interstitial chromosome (chr.) 1q21-q22 region is frequently amplified in human cancers, where it has been reported to carry prognostic significance for patients. We attempted to delineate chr. 1q21-q22 for affected gene(s) in hepatocellular carcinoma (HCC) by array-CGH and detected copy numb...

Read the complete abstract on PubMed

Topics

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Share to Carcinoma, Hepatocellular
Share to Epithelial Cells
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms

Share to Neoplasm Invasiveness

Share to Rho Guanine Nucleotide Exchange Factors

Share to rhoA GTP-Binding Protein

Share to RNA, Small Interfering

Source

Identifiers

PMID: 22847784
DOI: 10.1002/path.4084

Genes

MET
ROCK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22847784-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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