Article
Multivariate analysis reveals differentially expressed genes among distinct subtypes of diffuse astrocytic gliomas: diagnostic implications.
Scientific reports - 9 Jul 2020
González-García Nerea, Nieto-Librero Ana Belén, Vital Ana Luisa, Tao Herminio José, González-Tablas María, Otero Álvaro, Galindo-Villardón Purificación, Orfao Alberto, Tabernero María Dolores
Abstract excerpt
Diagnosis and classification of gliomas mostly relies on histopathology and a few genetic markers. Here we interrogated microarray gene expression profiles (GEP) of 268 diffuse astrocytic gliomas-33 diffuse astrocytomas (DA), 52 anaplastic astrocytomas (AA) and 183 primary glioblastoma (GBM)-based on multivariate analysis, to identify discriminatory GEP that might support precise histopathological tumor...
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