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Article

A glioma classification scheme based on coexpression modules of EGFR and PDGFRA.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2014

Sun Yingyu, Zhang Wei, Chen Dongfeng, Lv Yuhong, Zheng Junxiong, Lilljebjörn Henrik, Ran Liang, Bao Zhaoshi, Soneson Charlotte, Sjögren Hans Olov, Salford Leif G, Ji Jianguang, French Pim J, Fioretos Thoas, Jiang Tao, Fan Xiaolong

Abstract excerpt

We hypothesized that key signaling pathways of glioma genesis might enable the molecular classification of gliomas. Gene coexpression modules around epidermal growth factor receptor (EGFR) (EM, 29 genes) or platelet derived growth factor receptor A (PDGFRA) (PM, 40 genes) in gliomas were identified. Based on EM and PM expression signatures, nonnegative matrix factorization reproducibly clustered 1,369 adult...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24550449
DOI: 10.1073/pnas.1313814111
PMCID: PMC3948229

Genes

EGFR
PDGFRA

Provenance

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