Article
Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells.
Scientific reports - 8 Jul 2020
Dash Sabyasachi, Balasubramaniam Muthukumar, Martínez-Rivera Freddyson J, Godino Arthur, Peck Emily G, Patnaik Srinivas, Suar Mrutyunjay, Calipari Erin S, Nestler Eric J, Villalta Fernando, Dash Chandravanu, Pandhare Jui
Abstract excerpt
MiR-124 is a highly expressed miRNA in the brain and regulates genes involved in neuronal function. We report that miR-124 post-transcriptionally regulates PARP-1. We have identified a highly conserved binding site of miR-124 in the 3'-untranslated region (3'UTR) of Parp-1 mRNA. We demonstrate that miR-124 directly binds to the Parp-1 3'UTR and mutations in the seed sequences abrogate binding between the two RNA...
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