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Article

Avian major histocompatibility complex copy number variation is associated with helminth richness.

Biology letters - 1 Jul 2020

Minias Piotr, Gutiérrez Jorge S, Dunn Peter O

Abstract excerpt

Genes of the major histocompatibility complex (MHC) play a key role in the adaptive immunity of vertebrates, as they encode receptors responsible for antigen recognition. Evolutionary history of the MHC proceeded through numerous gene duplications, which increase the spectrum of pathogens recognized by individuals. Although pathogen-mediated selection is believed to be a primary driver of MHC expansion over...

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Identifiers

PMID: 32634375
DOI: 10.1098/rsbl.2020.0194
PMCID: PMC7423054

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