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Article

Maintenance tobramycin primarily affects untargeted bacteria in the CF sputum microbiome

6 Jul 2020

Abstract excerpt

RATIONALE: abundance and lung function diminish with continued therapy, this maintenance treatment is known to improve long-term outcomes, underscoring how little is known about why antibiotics work in CF infections, what their effects are on complex CF sputum microbiomes and how to improve these treatments. OBJECTIVES: To rigorously define the effect of maintenance tobramycin on CF sputum microbiome...

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PMID: 32631930
DOI: 10.1136/thoraxjnl-2019-214187

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