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Article

Genetic pathways involved in human speech disorders.

Current opinion in genetics & development - 1 Dec 2020

den Hoed Joery, Fisher Simon E

Abstract excerpt

Rare genetic variants that disrupt speech development provide entry points for deciphering the neurobiological foundations of key human capacities. The value of this approach is illustrated by FOXP2, a transcription factor gene that was implicated in speech apraxia, and subsequently investigated using human cell-based systems and animal models. Advances in next-generation sequencing, coupled to de novo paradigms,...

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PMID: 32622339
DOI: 10.1016/j.gde.2020.05.012

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