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Article

One for All: A Pooled Approach to Classify Functional Impacts of Multiple Mutations.

Cell stem cell - 2 Jul 2020

Jourdon Alexandre, Vaccarino Flora M

Abstract excerpt

Understanding common biological consequences of heterogenous mutations in complex polygenic conditions is challenging. In this issue of Cell Stem Cell, Cederquist et al. (2020) implement an in vitro pooled assay where 30 high-confidence ASD mutations engineered in subclones of a human pluripotent stem cell line can be investigated in parallel to reveal their effects on prefrontal cortex neurogenesis.

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Identifiers

PMID: 32619508
DOI: 10.1016/j.stem.2020.06.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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