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EIF2α phosphorylation is regulated in intracellular amastigotes for the generation of infective Trypanosoma cruzi trypomastigote forms.

Cellular microbiology - 1 Nov 2020

Castro Machado Fabricio, Bittencourt-Cunha Paula, Malvezzi Amaranta Muniz, Arico Mirella, Radio Santiago, Smircich Pablo, Zoltner Martin, Field Mark C, Schenkman Sergio

Abstract excerpt

Trypanosomatids regulate gene expression mainly at the post-transcriptional level through processing, exporting and stabilising mRNA and control of translation. In most eukaryotes, protein synthesis is regulated by phosphorylation of eukaryotic initiation factor 2 (eIF2) at serine 51. Phosphorylation halts overall translation by decreasing availability of initiator tRNAmet to form translating ribosomes. In...

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PMID: 32597009
DOI: 10.1111/cmi.13243

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