Article
A novel privacy-preserving federated genome-wide association study framework and its application in identifying potential risk variants in ankylosing spondylitis.
Briefings in bioinformatics - 20 May 2021
Wu Xin, Zheng Hao, Dou Zuochao, Chen Feng, Deng Jieren, Chen Xiang, Xu Shengqian, Gao Guanmin, Li Mengmeng, Wang Zhen, Xiao Yuhui, Xie Kang, Wang Shuang, Xu Huji
Abstract excerpt
Genome-wide association studies (GWAS) have been widely used for identifying potential risk variants in various diseases. A statistically meaningful GWAS typically requires a large sample size to detect disease-associated single nucleotide polymorphisms (SNPs). However, a single institution usually only possesses a limited number of samples. Therefore, cross-institutional partnerships are required to increase...
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