Article
Congenital mesoblastic nephroma is characterised by kinase mutations including EGFR internal tandem duplications, the ETV6-NTRK3 fusion, and the rare KLHL7-BRAF fusion.
Histopathology - 1 Oct 2020
Zhao Manli, Yin Minzhi, Kuick Chik Hong, Chen Huiyi, Aw Sze Jet, Merchant Khurshid, Ng Eileen Hui Qi, Gunaratne Sandini, Loh Amos Hong Pheng, Gu Weizhong, Tang Hongfeng, Chang Kenneth Tou En
Abstract excerpt
AIMS: Congenital mesoblastic nephroma (CMN) is histologically classified into classic, cellular and mixed subtypes. The aims of this study were to characterise the clinical, pathological and molecular features of a series of CMNs, and to determine the utility of pan-Trk and epidermal growth factor receptor (EGFR) immunohistochemistry as surrogate markers for NTRK gene fusions and EGFR internal tandem duplications...
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