Article
Positively selected variants in functionally important regions of TLR7 in Alouatta guariba clamitans with yellow fever virus exposure in Northern Argentina.
American journal of physical anthropology - 1 Sept 2020
Torosin Nicole S, Webster Timothy H, Argibay Hernán, Sanchez Fernandez Candelaria, Ferreyra Hebe, Uhart Marcela, Agostini Ilaria, Knapp Leslie A
Abstract excerpt
BACKGROUND: In 2007-2009, a major yellow fever virus (YFV) outbreak in Northern Argentina decimated the local howler monkey (Alouatta) population. AIMS: To evaluate whether the surviving howler monkeys possess advantageous genetic variants inherited from monkeys alive prior to the YFV outbreak, we explored the relationship between Toll-like receptor (TLR) 7 and TLR8 gene variation and YFV susceptibility. METHODS:...
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