Article
Pathogen-associated selection on innate immunity genes (TLR4, TLR7) in a neotropical rodent in landscapes differing in anthropogenic disturbance.
Heredity - 1 Oct 2020
Heni Alexander Christoph, Schmid Julian, Rasche Andrea, Corman Victor Max, Drosten Christian, Sommer Simone
Abstract excerpt
Toll-like receptors (TLRs) form part of the innate immune system and can recognize structurally conserved pathogen-associated molecular pattern (PAMP) molecules. Their functional importance in the resistance to pathogens has been documented in laboratory experimental settings and in humans. TLR diversity, however, has been rarely investigated in wildlife species. How the genetic diversity of TLRs is associated...
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