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Article

The function of GORASPs in Golgi apparatus organization in vivo

9 Jun 2020

Abstract excerpt

In vitro experiments have shown that GRASP65 (GORASP1) and GRASP55 (GORASP2) proteins function in stacking Golgi cisternae. However, in vivo depletion of GORASPs in metazoans has given equivocal results. We have generated a mouse lacking both GORASPs and find that Golgi cisternae remained stacked. However, the stacks are disconnected laterally from each other, and the cisternal cross-sectional diameters are...

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PMID: 32573693
DOI: 10.1083/jcb.202004191

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