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Article

Common Variants Coregulate Expression of GBA and Modifier Genes to Delay Parkinson's Disease Onset.

Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2020

Schierding William, Farrow Sophie, Fadason Tayaza, Graham Oscar E E, Pitcher Toni L, Qubisi Sara, Davidson Alan J, Perry Jo K, Anderson Tim J, Kennedy Martin A, Cooper Antony, O'Sullivan Justin M

Abstract excerpt

BACKGROUND: GBA mutations are numerically the most significant genetic risk factor for Parkinson's disease (PD), yet these mutations have low penetrance, suggesting additional mechanisms. OBJECTIVES: The objective of this study was to determine if the penetrance of GBA in PD can be explained by regulatory effects on GBA and modifier genes. METHODS: Genetic variants associated with the regulation of GBA were...

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Identifiers

PMID: 32557794
DOI: 10.1002/mds.28144
PMCID: PMC7496525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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