Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1.

Acta pharmacologica Sinica - 1 Mar 2021

Li Fang-Fang, Liang Yu-Lai, Han Xiao-Shuai, Guan Ya-Na, Chen Jian, Wu Ping, Zhao Xian-Xian, Jing Qing

Abstract excerpt

In the past two decades, purinergic signaling has emerged as a key regulator of hematopoiesis in physiological and pathological conditions. ADP receptor P2y12 is a crucial component of this signaling, but whether it is involved in primitive hematopoiesis remains unknown. To elucidate the function of P2y12 and provide new insights for drug development, we established a zebrafish P2y12 mutant by CRISPR/Cas 9-based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Nonmammalian
Share to Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocytes

Share to GATA1 Transcription Factor

Share to Gene Knockout Techniques

Share to Hematopoiesis

Share to Receptors, Purinergic P2Y12

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 32555443
DOI: 10.1038/s41401-020-0431-5
PMCID: PMC8027838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1.PMID 32555443Read ↗

Advances in understanding the mechanisms of erythropoiesis in homeostasis and diseaseSemantic proximity Read ↗

Use of the zebrafish system to study primitive and definitive hematopoiesis.Semantic proximity Read ↗

Using the Zebrafish as a Genetic Model to Study ErythropoiesisSemantic proximity Read ↗

Establishment of a Diamond-Blackfan anemia like model in zebrafish.Semantic proximity Read ↗

<i>rapunzel5</i> is necessary for normal hematopoietic development in zebrafishSemantic proximity Read ↗

Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia.Semantic proximity Read ↗

Growth and differentiation factor 11 (GDF11): Functions in the regulation of erythropoiesis and cardiac regenerationSemantic proximity Read ↗

The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene ExpressionSemantic proximity Read ↗

PIEZO1 activation delays erythroid differentiation of normal and hereditary xerocytosis-derived human progenitor cellsSemantic proximity Read ↗

Cloning of the zebrafish retsina blood mutation: a genetic model for dyserythropoiesis and erythroid cytokinesis.Semantic proximity Read ↗

Systematic transcriptome analysis of the zebrafish model of diamond-blackfan anemia induced by RPS24 deficiency.Semantic proximity Read ↗

Zebrafish erythropoiesis and the utility of fish as models of anemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.