Article
Activation-Induced Cytidine Deaminase Expression Facilitates the Malignant Phenotype and Epithelial-to-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma.
DNA and cell biology - 1 Jul 2020
Che Zhifei, Fan Jinfeng, Zhou Zhiyan, Li Qi, Ma Zhe, Hu Zhanhao, Wu Yaoxi, Jin Yingxia, Su Yang, Liang Peiyu, Li Haoyong
Abstract excerpt
Although advances have been made in the development of antiangiogenesis targeted therapy and surgery, metastatic clear cell renal cell carcinoma (ccRCC) is still incurable. Activation-induced cytidine deaminase (AID) is mainly expressed in a variety of germ and somatic cells, and induces somatic hypermutation and class-switch recombination, playing a vital role in antibody diversification. We confirmed that AID...
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