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Article

Effect of salbutamol on neuromuscular junction function and structure in a mouse model of DOK7 congenital myasthenia

11 Jun 2020

Abstract excerpt

Congenital myasthenic syndromes (CMS) are characterized by fatigable muscle weakness resulting from impaired neuromuscular transmission. β2-adrenergic agonists are an effective treatment for DOK7-CMS. DOK7 is a component within the AGRN-LRP4-MUSK-DOK7 signalling pathway that is key for the formation and maintenance of the synaptic structure of the neuromuscular junction (NMJ). The precise mechanism of action of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32543656
DOI: 10.1093/hmg/ddaa116

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