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Article

Cell-Clearing Systems Bridging Repeat Expansion Proteotoxicity and Neuromuscular Junction Alterations in ALS and SBMA.

International journal of molecular sciences - 4 Jun 2020

Limanaqi Fiona, Busceti Carla Letizia, Biagioni Francesca, Cantini Federica, Lenzi Paola, Fornai Francesco

Abstract excerpt

The coordinated activities of autophagy and the ubiquitin proteasome system (UPS) are key to preventing the aggregation and toxicity of misfold-prone proteins which manifest in a number of neurodegenerative disorders. These include proteins which are encoded by genes containing nucleotide repeat expansions. In the present review we focus on the overlapping role of autophagy and the UPS in repeat expansion...

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Identifiers

PMID: 32512809
DOI: 10.3390/ijms21114021
PMCID: PMC7312203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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