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Article

Hypoxia-induced shift in the phenotype of proteasome from 26S toward immunoproteasome triggers loss of immunoprivilege of mesenchymal stem cells.

Cell death & disease - 4 Jun 2020

Abu-El-Rub Ejlal, Sareen Niketa, Yan Weiang, Alagarsamy Keshav Narayan, Rafieerad Alireza, Srivastava Abhay, Desiderio Vincenzo, Dhingra Sanjiv

Abstract excerpt

Allogeneic mesenchymal stem cells (MSCs) are immunoprivileged and are being investigated in phase I and phase II clinical trials to treat different degenerative and autoimmune diseases. In spite of encouraging outcome of initial trials, the long-term poor survival of transplanted cells in the host tissue has declined the overall enthusiasm. Recent analyses of allogeneic MSCs based studies confirm that after...

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Identifiers

PMID: 32499535
DOI: 10.1038/s41419-020-2634-6
PMCID: PMC7272449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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