Article
Human norovirus targets enteroendocrine epithelial cells in the small intestine.
Nature communications - 2 Jun 2020
Green Kim Y, Kaufman Stuart S, Nagata Bianca M, Chaimongkol Natthawan, Kim Daniel Y, Levenson Eric A, Tin Christine M, Yardley Allison Behrle, Johnson Jordan A, Barletta Ana Beatriz F, Khan Khalid M, Yazigi Nada A, Subramanian Sukanya, Moturi Sangeetha R, Fishbein Thomas M, Moore Ian N, Sosnovtsev Stanislav V
Abstract excerpt
Human noroviruses are a major cause of diarrheal illness, but pathogenesis is poorly understood. Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patients. Abundant norovirus antigen and RNA are detected throughout the small intestinal tract in jejunal and ileal tissue from one pediatric intestinal transplant recipient with severe gastroenteritis. Negative-sense...
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