Article
Fragile X Gray Zone Alleles Are Associated With Signs of Parkinsonism and Earlier Death.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2020
Hall Deborah A, Nag Sukriti, Ouyang Bichun, Bennett David A, Liu Yuanqing, Ali Aisha, Zhou Lili, Berry-Kravis Elizabeth
Abstract excerpt
BACKGROUND: Premutation size (55-199 CGG repeats) in the fragile X mental retardation 1 (FMR1) gene cause fragile X-associated tremor/ataxia syndrome, but it is unclear whether smaller "gray" zone expansions of 41-54 repeats are also associated with movement disorders. The objectives of this study were to determine the association between the FMR1 gene gray zone expansions, AGG interspersions, and the presence of...
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