Article
PPARδ is a regulator of autophagy by its phosphorylation.
Oncogene - 1 Jun 2020
Gou Qian, Jiang Yidan, Zhang Runyun, Xu Ying, Xu Huihui, Zhang Wenbo, Shi Juanjuan, Hou Yongzhong
Abstract excerpt
In response to nutrient deficiency, autophagy degrades cytoplasmic materials and organelles in lysosomes, which is nutrient recycling, whereas activation of EGFR mediates autophagy suppression in response to growth factors. It is unclear whether PPARδ could be the regulator of autophagy in response to active EGFR. Here we found that EGFR induced PPARδ phosphorylation at tyrosine-108 leading to increased binding...
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