Article
The actin cytoskeletal network plays a role in yeast prion transmission and contributes to prion stability.
Molecular microbiology - 1 Sept 2020
Dorweiler Jane E, Oddo Mitchell J, Lyke Douglas R, Reilly Jacob A, Wisniewski Brett T, Davis Emily E, Kuborn Abigail M, Merrill Stephen J, Manogaran Anita L
Abstract excerpt
Chaperone networks are required for the shearing and generation of transmissible propagons from pre-existing prion aggregates. However, other cellular networks needed for maintaining yeast prions are largely uncharacterized. Here, we establish a novel role for actin networks in prion maintenance. The [PIN+ ] prion, also known as [RNQ+ ], exists as stable variants dependent upon the chaperone machinery for the...
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