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Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice

18 May 2020

Abstract excerpt

Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integration of up to more than 3 kilobases of exogenous DNA in the genome of hMSCs derived from the bone...

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PMID: 32424320
DOI: 10.1038/s41467-020-16065-3

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