Article
Gonadal dysfunction and beyond: Clinical challenges in children, adolescents, and adults with 47,<scp>XXY</scp> Klinefelter syndrome
16 May 2020
Abstract excerpt
Klinefelter syndrome (KS) is the most frequent sex chromosomal aneuploidy. The karyotype 47,XXY originates from either paternal or maternal meiotic nondisjunction during gametogenesis. KS males are very likely to exhibit marked gonadal dysfunctions, presenting both in severely attenuated spermatogenesis as well as hypergonadotropic hypogonadism. In addition, neurocognitive and psychosocial impairments, as well as...
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