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Article

Trans-ethnic meta-analysis of genome-wide association studies identifies maternal ITPR1 as a novel locus influencing fetal growth during sensitive periods in pregnancy.

PLoS genetics - 1 May 2020

Tekola-Ayele Fasil, Zhang Cuilin, Wu Jing, Grantz Katherine L, Rahman Mohammad L, Shrestha Deepika, Ouidir Marion, Workalemahu Tsegaselassie, Tsai Michael Y

Abstract excerpt

Abnormal fetal growth is a risk factor for infant morbidity and mortality and is associated with cardiometabolic diseases in adults. Genetic influences on fetal growth can vary at different gestation times, but genome-wide association studies have been limited to birthweight. We performed trans-ethnic genome-wide meta-analyses and fine mapping to identify maternal genetic loci associated with fetal weight...

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Identifiers

PMID: 32407400
DOI: 10.1371/journal.pgen.1008747
PMCID: PMC7252673

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