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Laminin α1 chain improves laminin α2 chain deficient peripheral neuropathy

7 Aug 2006

Abstract excerpt

Absence of laminin alpha2 chain leads to a severe form of congenital muscular dystrophy (MDC1A) associated with peripheral neuropathy. Hence, future therapies should be aimed at alleviating both muscle and neurological dysfunctions. Pre-clinical studies in animal models have mainly focused on ameliorating the muscle phenotype. Here we show that transgenic expression of laminin alpha1 chain in muscles and the...

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PMID: 16893907
DOI: 10.1093/hmg/ddl201

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