Article
N6-methyladenosine methyltransferase METTL3 affects the phenotype of cerebral arteriovenous malformation via modulating Notch signaling pathway.
Journal of biomedical science - 9 May 2020
Wang Lin-Jian, Xue Yimeng, Huo Ran, Yan Zihan, Xu Hongyuan, Li Hao, Wang Jia, Zhang Qian, Cao Yong, Zhao Ji-Zong
Abstract excerpt
BACKGROUND: Cerebral arteriovenous malformation (AVM) is a serious life-threatening congenital cerebrovascular disease. Specific anatomical features, such as nidus size, location, and venous drainage, have been validated to affect treatment outcomes. Until recently, molecular biomarkers and corresponding molecular mechanism related to anatomical features and treatment outcomes remain unknown. METHODS: RNA...
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