Article
Gene-expression profile reveals the genetic and acquired phenotypes of hyperactive mutant SPORTS rat.
The journal of medical investigation : JMI - 1 Jan 2020
Horiguchi Taigo, Miyatake Yumiko, Miyoshi Keiko, Tanimura Ayako, Hagita Hiroko, Sakaue Hiroshi, Noma Takafumi
Abstract excerpt
Spontaneously Running Tokushima Shikoku (SPORTS) rat is a hyperactive rat strain. However, the causative mutation of this phenotype has not yet been identified. To investigate the molecular basis for the unique phenotype of SPORTS rats, we examined gene-expression profiles by microarray analyses. Among adenylate kinase isozymes that maintain the homeostasis of cellular adenine nucleotide composition in the cell,...
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