Is there a role for HLA‐G in the induction of regulatory T cells during the maintenance of a healthy pregnancy?

Abstract excerpt

Abstract Problem Pregnancy remains an immune challenge for the uterus that has to adapt to a semi‐allogeneic fetus using various regulatory mechanisms. Both HLA‐G and regulatory T cells (CD4+ CD25+ FOXP3+ Tregs) are upregulated in successful pregnancy, but not in abortion. It is unclear if HLA‐G plays a role in the upregulation of regulatory cells. Method of Study We measured the level of both sHLA‐G and Treg...

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