Article
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2020
Hayashi Akimasa, Yavas Aslihan, McIntyre Caitlin A, Ho Yu-Jui, Erakky Amanda, Wong Winston, Varghese Anna M, Melchor Jerry P, Overholtzer Michael, O'Reilly Eileen M, Klimstra David S, Basturk Olca, Iacobuzio-Donahue Christine A
Abstract excerpt
Entosis is a type of regulated cell death that promotes cancer cell competition. Though several studies have revealed the molecular mechanisms that govern entosis, the clinical and genetic correlates of entosis in human tumors is less well understood. Here we reviewed entotic cell-in-cell (CIC) patterns in a large single institution sequencing cohort (MSK IMPACT clinical sequencing cohort) of more than 1600 human...
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