Article
The Role of Circulating Adiponectin and SNP276G>T at ADIPOQ Gene in BRCA-mutant Women.
Cancer genomics & proteomics - 1 Jan 2000
Daniele Antonella, Paradiso Angelo Virgilio, Divella Rosa, Digennaro Maria, Patruno Margherita, Tommasi Stefania, Pilato Brunella, Tufaro Antonio, Barone Michele, Minoia Carla, Colangelo Donatella, Savino Eufemia, Casamassima Porzia, Bruno Eleonora, Oliverio Andreina, Pasanisi Patrizia
Abstract excerpt
BACKGROUND: Environmental factors may influence the lifetime risk of cancer (penetrance) in women with a BRCA mutation. MATERIALS AND METHODS: In 89 BRCA-mutant women, affected or unaffected by breast/ovarian cancer, we explored serum levels of adipokines and their relation with the polymorphism SNP276G>T as modulators of BRCA penetrance. RESULTS: Affected women had significantly lower adiponectin than healthy...
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