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Article

Structural insights of catalytic mechanism in mutant pyrazinamidase of Mycobacterium tuberculosis.

Journal of biomolecular structure & dynamics - 1 Jun 2021

Junaid Muhammad, Li Cheng-Dong, Li Jiayi, Khan Abbas, Ali Syed Shujait, Jamal Syed Baber, Saud Shah, Ali Arif, Wei Dong-Qing

Abstract excerpt

Pyrazinamidase (PZase) is a member of Fe-dependent amidohydrolases that activates pyrazinamide (PZA) into active pyrazinoic acid (POA). PZA, a nicotinamide analogue, is an essential first-line drug used in Mycobacterium tuberculosis (Mtb) treatment. The active form of PZA, POA, is toxic and potently inhibits the growth of latent Mtb, which makes it possible to shorten the conventional 9-month tuberculosis...

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Source

Identifiers

PMID: 32340563
DOI: 10.1080/07391102.2020.1761879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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