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Article

Generation of two LRRK2 homozygous knockout human induced pluripotent stem cell lines using CRISPR/Cas9.

Stem cell research - 1 May 2020

Chen Shuhan, Luo Zhiwei, Ward Carl, Ibañez David P, Liu Hao, Zhong Xiaofen, Sharma Narendra K, Qin Baoming, Fan Wenxia, Wang Dongye

Abstract excerpt

Mutations in the Leucine rich repeat kinase 2 (LRRK2) gene are found in both familial and sporadic Parkinson's disease (PD), and are also associated with immune-related disorders including Crohn's disease (CD) and leprosy. We have generated two homozygous LRRK2 knockout human induced pluripotent stem cell (iPSC) lines using CRISPR-Cas9 in a well-characterized human iPSC clone. The LRRK2 knockout cell lines...

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Identifiers

PMID: 32339904
DOI: 10.1016/j.scr.2020.101804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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