Article
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Cancer cell - 11 May 2020
Dheilly Elie, Battistello Elena, Katanayeva Natalya, Sungalee Stephanie, Michaux Justine, Duns Gerben, Wehrle Sarah, Sordet-Dessimoz Jessica, Mina Marco, Racle Julien, Farinha Pedro, Coukos George, Gfeller David, Mottok Anja, Kridel Robert, Correia Bruno E, Steidl Christian, Bassani-Sternberg Michal, Ciriello Giovanni, Zoete Vincent, Oricchio Elisa
Abstract excerpt
Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We found that follicular lymphoma patients harbor a recurrent hotspot mutation targeting tyrosine 132 (Y132D) in cathepsin S (CTSS) that enhances protein activity....
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