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Article

Quantitative analysis of the BRAF V595E mutation in plasma cell-free DNA from dogs with urothelial carcinoma.

PloS one - 1 Jan 2020

Tagawa Michihito, Tambo Naomi, Maezawa Masaki, Tomihari Mizuki, Watanabe Ken-Ichi, Inokuma Hisashi, Miyahara Kazuro

Abstract excerpt

Circulating tumor DNA (ctDNA), which carries tumor-specific mutations, is an emerging candidate biomarker for malignancies and for monitoring disease status in various human tumors. Recently, BRAF V595E mutation has been reported in 80% of dogs with urothelial carcinoma. This study investigates the BRAF V595E allele concentration in circulating cell-free DNA (cfDNA) and assesses the clinical significance of...

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Share to Carcinoma, Transitional Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

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Share to Mutation, Missense

Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 32330187
DOI: 10.1371/journal.pone.0232365
PMCID: PMC7182225

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