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Centromere deletion in Cryptococcus deuterogattii leads to neocentromere formation and chromosome fusions

20 Apr 2020

Abstract excerpt

The human fungal pathogen Cryptococcus deuterogattii is RNAi-deficient and lacks active transposons in its genome. C. deuterogattii has regional centromeres that contain only transposon relics. To investigate the impact of centromere loss on the C. deuterogattii genome, either centromere 9 or 10 was deleted. Deletion of either centromere resulted in neocentromere formation and interestingly, the genes covered by...

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PMID: 32310085
DOI: 10.7554/elife.56026

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