Association of Antibiotic Exposure With Survival and Toxicity in Patients With Melanoma Receiving Immunotherapy.

doi:10.1093/jnci/djaa057

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Article

Association of Antibiotic Exposure With Survival and Toxicity in Patients With Melanoma Receiving Immunotherapy.

Journal of the National Cancer Institute - 1 Feb 2021

Mohiuddin Jahan J, Chu Brian, Facciabene Andrea, Poirier Kendra, Wang Xingmei, Doucette Abigail, Zheng Cathy, Xu Wei, Anstadt Emily J, Amaravadi Ravi K, Karakousis Giorgos C, Mitchell Tara C, Huang Alexander C, Shabason Jacob E, Lin Alexander, Swisher-McClure Samuel, Maity Amit, Schuchter Lynn M, Lukens John N

Abstract excerpt

BACKGROUND: Gut microbial diversity is associated with improved response to immune checkpoint inhibitors (ICI). Based on the known detrimental impact that antibiotics have on microbiome diversity, we hypothesized that antibiotic receipt prior to ICI would be associated with decreased survival. METHODS: Patients with stage III and IV melanoma treated with ICI between 2008 and 2019 were selected from an...

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Identifiers

PMID: 32294209
DOI: 10.1093/jnci/djaa057
PMCID: PMC7850522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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