Article
Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas.
Nature communications - 14 Apr 2020
Daniels Jay, Doukas Peter G, Escala Maria E Martinez, Ringbloom Kimberly G, Shih David J H, Yang Jingyi, Tegtmeyer Kyle, Park Joonhee, Thomas Jane J, Selli Mehmet E, Altunbulakli Can, Gowthaman Ragul, Mo Samuel H, Jothishankar Balaji, Pease David R, Pro Barbara, Abdulla Farah R, Shea Christopher, Sahni Nidhi, Gru Alejandro A, Pierce Brian G, Louissaint Abner, Guitart Joan, Choi Jaehyuk
Abstract excerpt
Primary cutaneous γδ T cell lymphomas (PCGDTLs) represent a heterogeneous group of uncommon but aggressive cancers. Herein, we perform genome-wide DNA, RNA, and T cell receptor (TCR) sequencing on 29 cutaneous γδ lymphomas. We find that PCGDTLs are not uniformly derived from Vδ2 cells. Instead, the cell-of-origin depends on the tissue compartment from which the lymphomas are derived. Lymphomas arising from the...
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